PEA Powder Mechanism Of Action, Benefits And Utilizes






PEA powder (544-31-0) Mechanism of Action


PEA activates the energy-boosting, fat-burning, and anti-inflammatory PPAR alpha. By activating this vital protein, PEA prevents the activity of pro-inflammatory genes and also the production of many inflammatory substances. PEA lessens the activity of this bliss gene FAAH that breaks down natural cannabinoid anandamide. This increases the levels of calming anandamide within your body, assisting combat pain and increase relaxation. It may also activate cannabinoid receptors (CB2 and CB1).

Palmitoylethanolamide contains the palmitic acid within its arrangement. The starting point for making PEA from the body is this saturated fatty acid. But simply increasing your intake of palmitic acid along with alternative dietary fats will not affect palmitoylethanolamide (pea) bulk powder production within your system. This is because your own body will utilize PEA only when it has to compensate for inflammation or pain, and also its degrees will probably also normally vary during your day. The very optimal/optimally way to find some great benefits of PEA are standardized dietary supplements, or alternatively PEA-rich meals. Check out WISEPOWDER site for fruitful information on pea now.


PEA Benefits and Programs

Chronic Regional Pain Syndrome (CRPS)

Intense regional pain syndrome (CRPS) describes a illness characterized by persistent, debilitating, and often-untreatable pain, changes into the quality of their afflicted individual's hair, skin, and nails, tremors/muscle spasms, and insomnia. In rare and severe cases, individuals suffering from CRPS may expertise nausea, muscular atrophy, and/or muscle contractures.

Nerve pain

Nerve pain encompasses a broad range of serious signs and symptoms that are induced by damage to the nerves that transfer information in your spinal cord into the skin and joints. Palmitoylethanolamide has been well-understood to be an efficient pain modulator, and has surfaced within fairly recent research as a potential therapeutic agent for several forms of chronic neuropathic pain. Palmitoylethanolamide is considered one among the most useful supplements to naturally deal with nerve pain.


A modern research has pointed to palmitoylethanolamide (pea) bulk powder as a potential natural retinoprotectant, or an agent that can combat pathogenic threats into the retinas and thus the eyesight. A 2015 evaluation released by the Journal of Opthalmology evaluated palmitoylethanolamide's therapeutic effects in the treatment of glaucomathat the second most prevalent cause of blindness. One randomized clinical trial at the review examined the outcomes of orally administered pea in comparison patients having an elevated intraocular pressure (or IOP, a significant contributing factor in glaucoma advancement ) and found that oral PEA significantly paid down the markers of IOP after two months of treatment.


A 2017 analyze published by BMC Veterinary Research evaluated the therapeutic effects of palmitoylethanolamide and quercetin, a plant flavonoid, in the treatment of osteoarthritis in animal issues. Researchers administered an oral fusion of palmitoylethanolamide co-ultramicronized with quercetin (PEA-Q) to laboratory rats exhibiting inflammatory and osteoarthritic pain and unearthed that PEA-Q decreased equally inflammatory and hyperalgesic reactions. Further, the PEA-Q enhanced locomotor role, secure cartilage against histological damage, and reduced mechanical allodynia.

Influenza and/or Common Cold

Nevertheless additional research is necessary to create a well-rounded pharmacological account of efficacy, some clinical evidence has indicated that palmitoylethanolamide may have an anti-influenza mechanism of action. A research assessment published by the International Journal of Inflammation evaluated data synthesized from PubMed within the past fifty years and found six clinical trials focusing on palmitoylethanolamide's therapeutic efficacy in the treatment of respiratory inflammation and flu. Available evidence points to palmitoylethanolamide as an entity capable of attenuating intestinal trauma and inflammation and soothes proinflammatory cytokine production in parasites that are parasitic. Researchers guessed that PEA may be able to de-escalate influenza and cool symptoms from down-modulating inflammatory cytokines and so restraining disease development.

Palmitoylethanolamide Dosage

At a 2017 safety evaluation, palmitoylethanolamide was determined to not cause genotoxic effects in human cells at doses of 1,000 mg/kg for a preliminary 14-day analyze. Even the LD 50, or lethal dosethat was greater than 2000 mg/kg. PEA is typically available in capsule form, frequently at a standard dosage of 400 milligrams each tablet, taken twice or thrice daily.

PEA can be ingested in powder and/or capsule form. It's also available as a non-steroidal topical cream for the aims of alleviating pain and inflammation.